Papers and Product Literature

A description of the papers and presentation documents that can be downloaded from our website follows below. All of these documents can be reproduced and distributed (to your colleagues and students) free of charge but they cannot be sold for profit. Most of the documents are zipped and you will need Winzip or a similar utility to decompress them after you download them. Click here to access a site for downloading Winzip. Bio and Batch Processing Documents The documents that follow are useful for engineers and scientists in the biotech, pharmaceutical, and specialty chemical industries that deal with development, design and operation of integrated batch processes. [1] Intelligen Suite (IntelligenSuiteFeb2009.zip, Size = 7 MB) This Powerpoint presentation document provides an overview of the Intelligen Suite (the combination of SuperPro Designer and SchedulePro). Most of the slides include descriptive text in the "Notes" page. Click here to download the document. If you wish to download a one-page flyer of the Intelligen Suite (in PDF format), please click here. [2] Design and Optimization of a Large Scale Biopharmaceutical Facility using Process Simulation and Scheduling Tools (BioPharmaFacilityDesign2010.zip, Size = 600 KB). An improved version of this article will be published in the March / April 2010 issue of Pharmaceutical Engineering (the ISPE magazine). The document is in PDF format and can be downloaded by clicking here. [3] The Role of Simulation and Scheduling Tools in the Development and Manufacturing of Active Pharmaceutical Ingredients (SimulationAndSchedulingInPharmaNov2009.zip, Size = 820 KB). An improved version of this document will become available as a chapter of a new book on “Chemical Engineering in the Pharmaceutical Industry: From R&D to Manufacturing” that will be published by John Wiley & Sons in 2010. The focus of this article is on small molecule active pharmaceutical ingredients (APIs). The document is in PDF format and can be downloaded by clicking here. [4] Systematic Evaluation of Single-Use Systems Using Process Simulation Tools (DisposablesNov2008.zip, Size = 236 KB). An improved version of this paper appeared in the November, 2008, supplement on Disposables of BioPharm International. This article evaluates the impact of single-use systems (disposables) on production cost, demand for cleaning materials, demand for consumables, and production cycle time. The analysis is done for a typical cell culture facility producing therapeutic monoclonal antibodies. The document is in PDF format and can be downloaded by clicking here. You may download the SuperPro Designer models for the two cases by clicking here. [5] Optimize Manufacturing of Pharmaceutical Products with Process Simulation and Production Scheduling Tools (IChemE_July_2007.zip, Size = 2.3 MB). This article appeared in the July 2007 issue of Chemical Engineering Research and Design (an IChemE publication). It provides information on the benefits from the use of process simulation and finite capacity scheduling tools in the development and manufacture of pharmaceutical products. An illustrative example focusing on Tablet Manufacturing is included. Topics covered in the article include: Materials Balances, Cost of Goods Analysis, Cycle Time Analysis and Reduction, Uncertainty and Variability Analysis, Production Planning and Scheduling. Click here to download the article. [6] Risk Assessment, Uncertainty/Variability Analysis, Stochastic Modeling, and Monte Carlo Simulation (RiskAssessmentPE2006.zip, Size = 18 MB). This article appeared in the July/August 2006 issue of Pharmaceutical Engineering (the main publication of ISPE). It explains how to represent uncertainty and variability in process models and assess its impact using the combination of SuperPro Designer and Crystal Ball. Crystal Ball is an Excel add-inn application that allows you to create scenarios for Monte Carlo simulation. The communication between Crystal Ball and SuperPro is done using the COM interface of SuperPro and scripts written in VBA (Visual Basic for Applications). The article is based on a batch API process and analyzes the impact of uncertainty and variability in cost and operating parameters on the annual throughput of the plant and its manufacturing cost. Click here to download the high-resolution version of the article. For a low-resolution version of the same file (which is only 220 KB in size), please click here. For a pertinent Powerpoint presentation, please click here. Most of the Powerpoint slides include descriptive text in the "Notes" pages. [7] Bioprocess Design & Economics Book Chapter (BookChpt.zip, Size = 511 KB) This document provides a nice introduction to Bioprocess Design & Economics. Biochemical engineering students and engineers with limited bioprocess design experience find it particularly useful. Since our first announcement, this document has been downloaded by more than 1000 engineers, professors, and students from around the world and has already been cited in several printed and on-line publications.  An improved version of this document is available as a chapter of a new textbook on "Bioseparations Science and Engineering" published by Oxford University Press. The document is in MS Word format and can be downloaded by clicking here. If you prefer the document in pdf format, please click here. And if you would like to order the complete book from Oxford University Press, click here. [8] Optimizing Pharmaceutical Process Development (PharmaPaper.zip, Size = 122 KB) This paper appeared in the Jan/Feb, 2002, issue of Pharmaceutical Engineering. It provides info on the role of batch process simulators in facilitating development and commercialization of bulk pharmaceuticals. The document is in pdf format (you will need Acrobat Reader to open it) and can be downloaded by clicking here. The same paper in MS Word 2000 format (the pictures have better resolution in this format) can be downloaded by clicking here. [9] Throughput Analysis and Debottlenecking of Biomanufacturing Facilities (BioPharmaPaper.zip, Size = 96 KB). A version of this article appeared in the August, 2002, issue of BioPharm. It focuses on debottlenecking and cycle time reduction of monoclonal antibody production processes. It provides info on a systematic debottlenecking theory and a thorough example based on a therapeutic MAb process. The document is in MS Word 2000 format and can be downloaded by clicking here. If you prefer the final version of the article in pdf format (size = 1300 kb), please click here. [10] Cycle Time Reduction and Economic Evaluation (AIChE2001.zip, Size = 524 KB) This is the Powerpoint document of a presentation on "Throughput Analysis, Debottlenecking, and Economic Evaluation of Integrated Biochemical Processes" that was given at the annual AIChE meeting in Reno (November, 2001). The complete text of the presentation can be found in the "Notes" page of the slides. It provides detailed info on a systematic throughput analysis and debottlenecking theory followed by a thorough example. The document also provides introductory material on process simulation and a future outlook regarding new features in SuperPro. Click here to download the document. [11] Process Fitting and Technology Transfer (SynPharma.zip, Size = 254 KB) This is the Powerpoint document of a presentation on "Technology Transfer, Process Fitting, and Debottlenecking". The complete text of the presentation can be found in the "Notes" page of the slides. This document deals with the transfer of a synthetic pharmaceutical process from R&D to manufacturing. It explains how to use process simulators to facilitate fitting of a new process into an existing facility and then how to increase plant throughput by installing extra equipment and operating it in an intelligent way. Click here to download the document. Third-Party Papers that Include SuperPro Models [12] Modeling the Process and Costs of Fuel Ethanol Production by the Corn Dry-Grind Process (USDA-Corn-to-Ethanol.zip, Size = 120 KB). This paper analyzes the production of fuel grade ethanol from corn using the dry-grind process. It includes technical as well as economic analysis of the process. SuperPro Designer was used for the analysis and the SuperPro model is available to the public for non-commercial research and educational uses. The work was performed by Jason R. Kwiatkowski, Andrew J. McAloon, Frank Taylor, and David B. Johnston at U.S. Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, 600 East Mermaid Lane, Wyndmoor, PA 19038-8598, USA. Click here to download the document. Click here to download the SuperPro file for this process. Please note that you will need SuperPro v7.5, build 8, to open and run this file. You may open and run the file even with the Evaluation version of SuperPro that can be downloaded from our website free of charge. If you wish to reach the authors of the paper and SuperPro model, please send an e-mail message to Mr. Andrew McAloon by clicking here. [13] Bio-Diesel Production from De-gummed Vegetable Oil (USDA_Biodiesel.zip, Size = 390 KB). This paper analyzes the production of biodiesel from degummed vegetable oil. It includes technical as well as cost analysis of the process. The process was modeled using Aspen Plus as well as SuperPro Designer. The SuperPro model is available to the public for non-commercial research and educational uses. The work was performed by Michael J. Haas, Andrew J. McAloon, Winnie C. Yess,, and Thomas A. Foglia at U.S. Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, 600 East Mermaid Lane, Wyndmoor, PA 19038-8598, USA. Click here to download a zip file that includes the paper and the SuperPro process model.  Please note that you will need SuperPro v6, build 21, to open and run this file. You may open and run the file even with the Evaluation version of SuperPro that can be downloaded from our website free of charge. [14] Production of Polyhydroxyalkanoates from Renewable Carbon Resources (Akiyama.zip, Size = 440 KB). This paper analyzes the large-scale fermentative production of poly(3-hydroxybuturate-co-5mol%  3-hydroxyhexanoate) [P(3HB-co-5mol% 3HHx)] from soybean oil as sole carbon source. It includes results of cost analysis and environmental impact assessment. SuperPro Designer was used for the analysis. The work was performed by Minoru Akiyama, Takeharu Tsuge, and Yoshiharu Doi at the Tokyo Institute of Technology (Japan). Click here to download the document. [15] Design of processes for the recovery and purification of plasmids for gene therapy and DNA vaccination (Prazeres.zip, Size = 240 KB). This paper gives an overview of the manufacturing of plasmids and provides the basic concepts for designing flowsheets for their recovery and purification. Various alternatives flowsheets are presented and analyzed with SuperPro Designer. The work was performed by D.M.F. Prazeres and G.N.M. Ferreira at the Instituto Superior Tecnico in Lisbon, Portugal. Click here to download the document. Product Formulation and Packaging [16] This presentation file (in Powerpoint 97 format) explains how SuperPro Designer can be used to model, visualize, and optimize product formulation and packaging lines. It is applicable to professionals in the food, consumer product, pharmaceutical, beverage, and related industries. Essentially, whenever there is a combination of batch and semi-continuous lines that share some equipment, SuperPro can be used to reduce cycle times and increase plant throughput. To download this file (size = 148 KB) click here. Wastewater Treatment, Water Purification and Air Pollution Control The documents that follow are useful for engineers that deal with wastewater treatment (physical as well as biological treatment), water purification, and recycling. [17] Analysis and Retrofit Design of Wastewater Treatment and Recycling Facilities Using Process Simulation (EnvECB12.zip, Size = 708 KB). This PowerPoint document explains how process simulators can facilitate modeling, cost analysis, and optimization of wastewater treatment processes (municipal as well as industrial). Issues of VOC emissions from industrial treatment plants are addressed. A water recycling example is also included. Most slides include descriptive text in the "Notes" pages. Click here to download the document. [18] The Role of Process Simulation in Evaluating Water Recycling Opportunities at a Semiconductor Fabrication Facility (Water2000.zip, Size = 159 KB). This paper was presented at the International Water Conference in Pittsburgh in October of 2000 It describes an effort to apply process simulation for evaluating water recycling options at a semiconductor fabrication plant of Lucent Technologies (presently that plant belongs to Agere Systems). The process described is also available as an example in the current demo version of SuperPro Designer. Click here to download the document. [19] Click here to download the Powerpoint presentation document for the above paper (IWC2000.zip, Size = 663 KB). The focus of the presentation is on water recycling at a semiconductor manufacturing plant. However, the principles and ideas can be readily extended to other industrial facilities that utilize large amounts of water and have a need for recycling. The complete text of the presentation can be found in the "Notes" page of the slides. [20] Optimization of Wastewater Treatment Facilities using Process Simulation (WasteWater1.zip, Size = 516 KB, the original document is in pdf format). This article was published in Computers and Chemical Engineering in 1998. It deals with modeling, evaluation, and optimization of wastewater treatment processes. Models for predicting VOC emissions and tracking the fate of regulated components are presented in detail. Click here to download the document. [21] EnviroPro Designer brochure (EnvPro.zip, Size = 164 KB) This brochure document (in MS Word 97 format) provides detailed information on the capabilities and features of EnviroPro Designer. EnviroPro is a subset of SuperPro that focuses on wastewater treatment (physical as well as biological), water recycling, and air pollution control applications. Click here to download the document. [22] Additional publications on wastewater treatment applications. You may also try to locate in your library the following articles. If you have difficulty gaining access to them, please let us and we will send you copies: Clean Water Begins with a Mouse - A comprehensive computer simulation can simplify the task of designing a cost-effective wastewater treatment plant, Demetri Petrides, John Calandranis and Joseph Flora, Industrial Wastewater (a WEF publication), May/June 1997 issue, Pp. 33-40. Modeling and Optimization of a Municipal Treatment Plant Using EnviroPro Designer, Victor E. Santamarina, Environmental Progress (Vol. 16, No. 4), Winter 1997, Pp. 268-273. Treatment plant instructional modules based on SuperPro Designer v2.7, Joseph R.V. Flora, A. Steve McAnally, and Demetri Petrides, Environmental Modelling & Software, Elsevier, Vol. 14, 1999, Pp. 69-80. [23] Finally, the demo version of SuperPro comes with five additional environmental examples (see the list below). Each example comes with a detailed read me file. International Process Design Contest - Awards for 2006 In 2006 we initiated an International Process Design Contest for work performed by students using SuperPro Designer. The following three contributions won the awards. FIRST AWARD - Simulation of a Process for Manufacturing of Clopidogrel Bisulfate (the active ingredient in Plavix, an anti-platelet medication marketed by Bristol-Myers Squibb and Sanofi-Aventis). Submitted by Milana Trifkovic and Sandra Cardoso from the Chemical & Biochemical Engineering department of the University of Western Ontario, Canada. Click here to download a zip file that includes the report in MS Word format and the SuperPro model of the process. SECOND AWARD - Economic Analysis of Cellulase Production Methods for Bio-Ethanol: Comparison of Liquid Versus Solid State Cultivation Approaches. Submitted by Jun Zhuang from the University of Wisconsin-Madison. However, he performed this work while he was a student at the University of Kentucky. Click here to download a zip file that includes the report in PDF format and two SuperPro files. THIRD AWARD - Design and Economic Analysis of Industrial Production of Fructosyltransferase. Submitted by Katarína Vaňková from the Slovak University of Technology in Slovakia.  Click here to download a zip file that includes the report in MS Word format and the SuperPro model of the process. International Process Design Contest - Award for 2007 Commercial Production of Anti-Cancer Agent Paclitaxel (the active ingredient in Taxol). Submitted by Nirav Patel and Shaena Steward from the Chemical & Environmental Engineering department of the University of California Riverside. Click here to download a zip file that includes the report in PDF format and the SuperPro files of the process. You will need SuperPro v7.0 to open the above SuperPro files. Click here to download the FREE Evaluation version of SuperPro v7.0.